Anti-norovirus capsid protein VP1 antibody
Rabbit polyclonal to norovirus VP1 capsid protein
Species reactivity: Norovirus Hu / Texas / TCH04-577 / 2004 / US
Reacts with: Other species
A synthetic peptide corresponding to the capsid protein of norovirus VP1 (N terminal).
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2. Storage instructions
Shipped at 4 ° C. Upon delivery, aliquot, and store at -20 ° C. Avoid freeze/thaw cycles.
3. Storage buffer
4. Preservative: 0.01% sodium azide
Components: PBS, 50% glycerol
50 µg to 0.5 mg / ml
Immunogenic affinity purified
7. Purification notes
Norovirus is an RNA virus in the taxonomic family Caliciviridae, causing approximately 90% of non-bacterial gastroenteritis outbreaks worldwide and responsible for 50% of all foodborne gastroenteritis outbreaks in the US. Norovirus affects people of all ages. Viruses are transmitted through food or water contaminated with feces and through person-to-person contact.
Noroviruses contain a positive-sense RNA genome of approximately 7.5 kbp, which encodes a major structural protein (VP1) of approximately 58 ~ 60 kDa and a secondary capsid protein (VP2). Virus particles show an amorphous surface structure when viewed by electron microscopy and are between 27 and 38 nm in size. The VP1 capsid protein binds the virion to the target cells by binding the histo-blood group antigens present on the gastroduodenal epithelial cells. Soluble capsid protein may play a role in viral immunoevasion.
The VP1 capsid protein binds to host blood group antigens on the surface of target cells. The layer domain (S domain) contains essential elements for the formation of the icosahedron. The overhang domain (P domain) is divided into subdomains P1 and P2. The P domain interacts in dimeric contacts that increase the stability of the capsid and form the bumps in the virion. A hypervariable region in P2 is believed to play an important role in receptor binding and immune reactivity.